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International Journal of Pediatric Frontiers. 2016; 43: (1) 5; .

Comparative efficacy, acceptability and safety of 5 new-generation antipsychotics in treatingfirst-epi-sode schizophrenia.
5种新一代抗精神病药治疗首发精神分裂症的对照研究

作者: 石文杰*,王从杰, 朱建南 ,陈 刚,黄成兵

江苏省港安市第三人民医院

江苏省港安市第三人民医院

江苏省港安市第三人民医院

江苏省港安市第三人民医院

江苏省港安市第三人民医院

*通讯作者:石文杰,单位:江苏省港安市第三人民医院;

引用本文: 石文杰,王从杰, 朱建南,陈 刚,黄成兵. 5种新一代抗精神病药治疗首发精神分裂症的对照研究. 国际儿科前沿杂志, 2016, 43(1) : 24-27.
Published:

摘要

比较利培酮、喹硫平、 奥氮平、 阿立哌唑和齐拉西酮治疗首发精神分裂症的疗效、 可接受性及安全性。方法 将200例首发精神分裂症患者随机给予上述5种之一的新一代抗精神病药治疗; 采用 «简明精神病量表» 评定临床疗效, 同时比较5种抗精神病药物的可接受性(合并用药率、换药率及维持原药率)和不良反应。结果 ①临床疗效:阿立v張良吐、利培西同、空石流平、 奥氮平、 齐拉西西同治疗首发精神分裂症患者后 BPRS评分较治疗前差异均有统计学意义(P<0. 01) ; 经方差分析和 LSD检验提示, 利培西同组 BPRS减分率显著高于阿立口透良生纽 (P<0. 01) 和奥氮平组(P<0.05)。②可接受性比较:经K2检验提示(X2=15.55, P=0.049);经过分割Z2 检验, 奥氮平较阿立来良9坐、 齐拉西西]司差异均有统计学意义 ( P<0. 05 ) ; 同时空石索平较齐拉西産l同差异也有统计学意义(P<0.05)。③不良反应比较:在体体外系反应、 ECG改变、肝功能异常、便秘、白细胞减少5个方面差异均无统计学意义(均 P>0.05)。结论 5种新一代抗精神病药治疗精神分裂症首次发病患者疗效均较好, 奥氮平、 空石流平可接受性较好; 5种药物之间不良反应类似。

关键词: 首发;精神分裂症;抗精神病药;疗效;可接受性和安全性

Abstract

〇bjective To explore the efficacy, acceptability and safety of 5 new - generation antipsychotics (e g. aripiprazole, resperidone, quetiapine, olanzapine, ziprasidone) in treating first - episode schizophrenia.
Methods 200 cases of first-episode schizophrenia were recruited and randomly given one of 5 new-generation anti- psychotics respectively when inclusion. Clinical efficacy was assessed by Brief Psychiatric Rating Scale, acceptabili- ty was evaluated mainly by drug combination, change another medication proportion and maintain original drug rate of each antipsychotics, and safety of each anLipsychotics were estimated by its side effects.
Results 1. BPRS scores after treatment were all significantly decreased than prior treatment in each of 5 new-generation antipsychotics(all P value<0.01). While BPRS reduction scores of resperidone were markedly higher Lhan thaL of aripiprazole (P< 0.01) and olanzapine (f)<0.05) 2. Acceptability of olanzapine was remarkably better than that of aripiprazole (P =0.027) and ziprasidone (P=0.015) , meanwhile, quetiapine was also markedly better than that of ziprasidone (P=0.037). 3.The difference of EPS, changes of ECG, abnormal liver functions, constipation and leukopenia a- mong5 new-generation antipsychotics were not detected.
Conclusion   The efficacy of 5 new - generation antipsy- chotics in treating 「irst-episode schizophrenia were all significant, The accepLability of olanzapine and quetiapine were better among5 new-generation antipsychotics, Side effects of 5 new-generation antipsychotics were similar.

Key words: First-episode; Sichizophrenia; Antipsychotics; Efficacy; Acceptability and safety

参考文献 References

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