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International Journal of Pediatric Frontiers. 2016; 43: (1) 8; .

Quetiapine treatment of psychiatric patients with biphasic acute mania efficacy and safety.
奎硫平治疗精神科双相急性躁狂症患者的疗效及安全性

作者: 徐缓*,朱文浩, 徐曲荣,成亚纯,胡本善

湖北省应城市人民医院

华中科技大学附属同济医院

湖北省应城市人民医院

湖北省应城市人民医院

湖北省应城市人民医院

*通讯作者:徐缓,单位:湖北省应城市人民医院;

引用本文: 徐缓,朱文浩, 徐曲荣,成亚纯,胡本善. 奎硫平治疗精神科双相急性躁狂症患者的疗效及安全性. 国际儿科前沿杂志, 2016, 43(1) : 54-56.
Published:

摘要

目的 本研究诣在探讨空石流平治疗双相心境障碍急性躁狂发作的临床效果及安全性。 方法 选取笔者科室92例确诊双相心境障碍急性躁狂发作患者依据入院顺序分为 a蛋i流平纽和破酸i里组各46例, 两组患者均连续治疗6周,观察两组患者的临床治疗效果及不良反应发生率差异。 结果治疗后第3周、第6周空石流平组的躁狂评分(18.5±3.6)分、(11.5±2.4)分均显著的低于破酸i里组的(21.6±3.9)分、(14.3±3.0)分(P<0.05)。治疗后第3周、第6周查石流平组的躁狂评分减分率 (24. 18±8. 17)%、 (52. 87±21. 64)%均显著的高于破酸4里组的 ( 13. 60±7. 03)%、(42. 80±19.33)% (P<0.05)。治疗后第6周全石流平组的愈显率(69.57%) 均显著的高于破酸i里组的(91.30%) (P<0.05)。 空疏平组的不良反应率(10.87%)显著的低于破酸使组的(28. 26%) (P<0. 05) 。 结论 畦疏平治疗双相心境障碍急性躁狂发作的临床效果确切, 不良反应发生率更低。

关键词: 喹硫平;双相心境障碍;急性躁狂发作;临床效果;安全性

Abstract

〇bjective This study was to explore Yi quetiapine to treat bipolar mood disorder acute manic ep- isodes clinical efficacy and safety.
Methods The author selected department92 cases diagnosed bipolar disorder patients with acute manic episodes according to the order of admission into quetiapine group and46 cases each I,ithi_ urn carbonate group, patients were treated for6 consecutive weeks, the two groups of patients in clinical treatment and differences in the incidence of adverse reactions.
Results After three weeks of treatment, the first six weeks of quetiapine group mania score(18.5±3. 6) points, (11. 5±2.4) scores were significantly1ower than Lithium car- bonate group(21.6±3.9) points, (14.3±3.0) min(P<0.05). After three weeks of treatment, Lhe first six weeks of quetiapine manic score reduction rate(24. 18±8. 17)%, (52.87±21.64)% were significantly higher than Lithium carbonate group(13. 60±7. 03)%, (42. 80±19. 33)% (P<0. 05). After treatment markedly effec- tive rate (69.57%) first six weeks quetiapine group were significantly higher than Lithium carbonate group (91.30%) (P<0.05). Adverse reaction rates(10.87%) was significantlylower than Lithium carbonate group (28.26%) (P<0.05) quetiapine group.
Conclusion   Quetiapine to treat bipolar mood disorder acute manic epi-sodes exact clinical effect, lower incidence of adverse reactions.

Key words: Quetiapine; Bipolar disorder; Acute manic episodes; Clinical results; Safety

参考文献 References

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