International medical research frontier 2017; 1: (1) 2; DOI:10.20900/imrf.20170002.
[Abstract] Objective: To investigate the influences of glycyrrhizic acid diammonium capsules combined with bicyclic alcohol tablets in the treatment of autoimmune hepatitis on immunological indicators and the degree of liver fibrosis. Methods: 80 patients with autoimmune hepatitis were divided into two groups by random number table (n=40). The control group was treated with diammonium glycyrrhizinate alone. The combined group increased bicyclol tablets on the basis of the control group. Then compared the immunological indicators, liver fibrosis indicators, clinical efficacy and so on of two groups. Results: The levels of ALT, AST and liver cirrhosis in the combined group were significantly lower than control group (P<0.05). After treatment, the levels of IgG and γ-globulin in both groups were significantly decreased (P<0.05), but there was no significant difference between the two groups (P>0.05). The total score of symptoms in the combined group was significantly lower than that in the control group (P<0.05). The total effective rate of the combination group was 87.50%, which was significantly higher than that of the control group (60.00%, P<0.05). Conclusion : Glycyrrhizic acid diammonium capsules combined with bicyclic alcohol tablets in the treatment of autoimmune hepatitis can effectively regulate the immune function, reduce the degree of liver fibrosis and improve clinical efficacy.