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International medical research frontier 2017; 1: (1) 1; DOI:10.20900/imrf.20170001.

Observe the effect of anti-oxidant free radical therapy to reduce the frequency of seizures and epileptiform discharges
抗氧自由基治疗对减少癫痫发作频数及痫样放电的效果观察

作者: 向军1*

1 中南大学湘雅二医院

*通讯作者:向军,单位:中南大学湘雅二医院;邮箱:xyxiangjun@csu.edu.cn

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引用本文: 向军. 抗氧自由基治疗对减少癫痫发作频数及痫样放电的效果观察. 国际医药研究前沿, 2017, 1(1): -.
Published: 2017-12-25

摘要

【摘要】目的:探讨抗氧自由基治疗对减少癫痫发作频数与痫样放电的临床疗效。
方法:选取本院收治的98例癫痫患者作为研究对象,使用随机数字表法分为两组(n=49),对照组给予抗癫痫基础治疗,观察组在对照组基础上加用维生素E、维生素C,观察两组患者治疗前后的癫痫发作频数及痫样放电情况。
结果:观察组患者的癫痫发作频数治疗总有效率为93.88%,显著高于对照组的65.31%(P<0.05)。观察组患者痫样放电的治疗总有效率为89.80%,对照组为71.43%,组间比较有显著性差异(P<0.05)。两组的不良反应发生率比较无显著性差异(P>0.05)。观察组治疗后的MOCA延迟记忆、注意评分及总评分均显著高于对照组(P<0.05)。
结论:抗氧自由基辅助治疗癫痫,能够有效减少癫痫发作频数与痫样放电,同时还有助于提高患者的认知功能,其临床效果确切。

关键词: 【关键词】癫痫;抗氧自由基;痫样放电;维生素C;维生素E

Abstract

[Abstract] Objective: To investigate the clinical efficacy of anti-oxidant free radical therapy to reduce the frequency of seizures and epileptiform discharge.
Methods: 98 epilepsy patients were divided into two groups by random number table (n=49). The control group accepted basic antiepileptic treatment, and the observation group increased vitamin E and Vitamin C. Then observed the seizure frequency and epileptiform discharge situation before and after treatment of two groups.
Results: The total effective rate of seizure frequency in observation group was 93.88%, which was significantly higher than 65.31% of control group (P<0.05) . The total effective rate of epileptiform discharge was 89.80% in observation group and 71.43% in control group, there was a significant difference between the two groups (P<0.05). There was no significant difference in the incidence of adverse reactions between the two groups (P>0.05). The delayed memory, attentional score and MOCA total scores in the observation group were significantly higher than those in the control group (P<0.05).
Conclusion  : The anti-oxygen free radical adjuvant treatment of epilepsy can effectively reduce the frequency of seizures and epileptiform discharges, and also help to improve the cognitive function of patients. It has exact clinical efficacy.

Key words: [Key words] Epilepsy; Antioxidant free radicals; Epileptiform discharges; Vitamin C; Vitamin E

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