International Journal of Surgical Research. 2018; 1: (2) 1; DOI:10.12208/j.ijsr.20180002.
目的：观察脑室-腹腔分流术（VPS）治疗新型隐球菌脑膜炎（CM）合并颅内高压的可行性及安全性。方法：选取80例CM 合并颅内高压患者作为研究对象，将其分为研究组和对照组，其中对照组进行常规治疗，研究组给予VPS治疗，观察并比较两组患者治疗前后的临床表现、脑脊液情况及两组患者的疗效和不良反应发生情况。结果：治疗后，研究组临床表现及脑脊液情况明显优于对照组，且差异均有统计学意义（P＜0.05）；研究组总有效率明显高于对照组（95% vs 70%），且差异有统计学意义（P＜0.05）。研究组不良反应发生率明低于对照组，且差异具有统计学意义（P＜0.05）。结论：VPS是治疗CM合并颅内高压的一种安全、有效的手术方式，能明显提高患者的生存质量，值得临床推广应用。
Objective：Discussion VPS merger of cryptococcus neoformans encephalitis intracranial hypertension patients feasibility and safety. Methods:80 cases of CM with intracranial hypertension were selected and divided into study group and control group. The control group was treated with conventional therapy and the study group was treated with VPS. And the clinical manifestations and cerebrospinal fluid before and after surgery, and the efficacy and adverse reactions of two groups were observed and compared . Results: After treatment, the clinical manifestations and cerebrospinal fluid of the study group were significantly better than those of the control group，and the differences were statistically significant(P<0.05).The total efficiency in the observation group was significantly higher than that in the control group，and the difference was statistically significant(P<0.05).The adverse reactions in the observation group was significantly lower than that in the control group，and the difference was statistically significant(P<0.05). Conclusions:VPS is a safe and effective surgical method to treat CM combined with intracranial hypertension. It can obviously improve the quality of life of patients and is worth clinical application.