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International medical research frontier. 2018; 2: (1) 2; DOI:10.20900/j.imrf.20180002.

Progression of multi-omics research in gliomas
神经胶质瘤多组学研究进展

作者: 杨海燕,詹显全*

中南大学湘雅医院卫生部肿瘤蛋白质组学重点实验室、结构生物学与药物设计、湖南省工程实验室、抗癌药物国家地方联合工程实验室 (长沙,410008)

*通讯作者:詹显全,单位:中南大学湘雅医院卫生部肿瘤蛋白质组学重点实验室、结构生物学与药物设计、湖南省工程实验室、抗癌药物国家地方联合工程实验室 (长沙,410008);邮箱:yjzhan2011@gmail.com

引用本文: 杨海燕,詹显全. 神经胶质瘤多组学研究进展. 国际医药研究前沿, 2018, 2(1)
Published: 2018-09-10

摘要

神经胶质瘤作为最常见的原发中枢神经系统肿瘤,具有很大的异质性。越来越多的研究表明,神经胶质瘤是一个多基因、多蛋白质参与的多阶段发展的疾病,并与基因组、转录组、蛋白质组及表观遗传组的异常关系密切。不同组学的研究给神经胶质瘤研究注入了系统的视角,各个组学之间并非相互孤立或单项流动,具有相互作用及双向及多向流动的特点。本文对神经胶质瘤多组学研究的进展进行综述。

关键词: 神经胶质瘤,基因组学,转录组学,蛋白质组学

Abstract

Glioma, as one of the most common primary tumors in central nervous system, has a great heterogeneity. More and more studies have shown that glioma is a multigene- and multiprotein-involved multi-stage developed disease, and is closely related to genome, transcriptome, proteome and epigenetic abnormalities. Different omics studies have provided a systematic perspective into the research of glioma, and each omics is not isolated or single-flowing. That is to say, they have the characteristics with close relationship and two-way or multi-directional flow by each other. This article comprehensively reviews the progress of multi-omics research in gliomas.

Key words: Glioma,genomics,transcriptomics,proteomics

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